The global expression of immune response genes in infants after vaccination and their role in asthma and allergy

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Anne I. Lahdenper¨aa
, Lennart J. Nilssona
, Karin Regnstr¨omb,c,∗
a Division of Paediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences,
Linkoping University, 58185 Link ¨ oping, Sweden ¨ b Department of Pharmacy, Uppsala University, Box 580, 75123 Uppsala, Sweden
c Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut,
69 North Eagleville Road, Storrs, CT 06269, United States
Received 22 May 2007; received in revised form 13 December 2007; accepted 23 January 2008
Available online 13 February 2008

KEYWORDS
Pharmacogenomics;
Asthma;
Allergy

Summary The global expression of immune response genes in infants after vaccination and
their role in asthma and allergy is not clearly understood. Pharmacogenomics is ideally suited to
study the involved cellular responses, since the expression of thousands of genes can be assessed
simultaneously. Here, array technology was used to assess the expression kinetics of immune
response genes with association to asthma and allergy in peripheral blood mononuclear cells
(PBMC) of five healthy infants after vaccination with Infanrix-Polio + Hib. At 12 h after in vitro
re-stimulation of the PBMC with pertussis toxin (PT) antigen, 14 immune response pathways,
33 allergy-related and 66 asthma-related genes were found activated.
© 2008 Elsevier Ltd. All rights reserved.

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